The 29-year-old was taken off the field at Aston Villa on Saturday, but it was reported that this was purely precautionary, but the club now fear he could well miss some very important games which are coming up.
Manager Steve Kean fears that Santa Cruz could miss Wednesday’s game with Tottenham but hopeful he will be back for the clash with Wigan on Saturday.
Kean said: "Roque tweaked his groin. We got him off the pitch, iced up and hopefully it will settle down.
"I think he will be doubtful for the Tottenham game but hopefully he should be okay for Wigan."